Efficient heterologous antigen gene delivery and expression by a replication-attenuated BoHV-4-based vaccine vector.

Antonio Capocefalo,Carlo Mangia,Valentina Franceschi,Sarah Jacca,Vicky L van Santen,Gaetano Donofrio

Vaccine（2013）

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摘要

•BoHV-4-based vector is a good candidate as a vaccine vector for veterinary vaccinology.•BoHV-4 genome possesses a large non coding RNA gene (L1.7).•BoHV-4 coding RNA gene (L1.7) deletion increase BoHV-4-based vector safety.

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关键词

Bovine herpesvirus 4,Recombinant virus,Gene deletion,Non-coding RNA,Viral vector

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