Combined measurement of N-terminal pro-B-type natriuretic peptide and highly sensitive cardiac troponin T for diagnosis and monitoring of heart injury in chronic Chagas' disease.

•hs-cTnT and NT-proBNP increase with the severity of Chagas’ heart disease.•Dual positivity of both markers most successfully predicted Chagas’ cardiomyopathy.•Dual negativity of both markers is most appropriate to exclude cardiomyopathy.•An algorithm to diagnose and monitor chronic Chagas’ patients was suggested.•Pre-test probability of cardiologic diagnostics increases this way.