Parthenolide reverses doxorubicin resistance in human lung carcinoma A549 cells by attenuating NF-κB activation and HSP70 up-regulation.

Yinqiang Xin,Fei Yin,Shimei Qi,Lei Shen,Yimiao Xu,Lan Luo,Lei Lan,Zhimin Yin

Toxicology Letters（2013）

引用 31|浏览2

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摘要

•Parthenolide enhanced the cytotoxic effect of DOX on A549/DOX cells.•Parthenolide suppressed P-gp expression by inhibiting NF-κB activation.•HSP70 upregulation was positively correlated with P-gp upregulation.•Parthenolide effectively attenuated the HSP70 upregulation in A549/DOX cells.

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关键词

Parthenolide,Doxorubicin resistance,P-glycoprotein,NF-κB,HSP70

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