Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster.

Brigitta Kiss,Tamás Szlanka,Ágnes Zvara,Michal Žurovec,Michal Sery,Štefan Kakaš,Beáta Ramasz,Zoltán Hegedűs,Tamás Lukacsovich,László Puskás,Adrien Fónagy,István Kiss

General and Comparative Endocrinology（2013）

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摘要

•RNAi knockdown of FaRP genes decreased startle-induced locomotor activity of flies.•Three Gal4 drivers were constructed with 5′ regulatory sequences of the Fmrf gene.•The new drivers express Gal4 in partial FMRF neuronal pattern and some ectopic cells.•Cell ablation targeted by the new drivers can also influence adult locomotor activity.

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关键词

Drosophila melanogaster,FMRF-related peptides,G protein-coupled receptors,RNAi-silencing,UAS-reaper ablation,Locomotor activity

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