Emergence of resistance-associated variants after failed triple therapy with vaniprevir in treatment-experienced non-cirrhotic patients with hepatitis C-genotype 1 infection: a population and clonal analysis.

Richard J O Barnard,Carolyn M McHale,William Newhard,Carol A Cheney,Donald J Graham,Amy L Himmelberger,Julie Strizki,Peggy M T Hwang,Amber A Rivera,Jacqueline D Reeves,David Nickle,Mark J Dinubile,Daria J Hazuda,Niloufar Mobashery

Virology（2013）

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摘要

•Vaniprevir plus P/R is efficacious in patients with hepatitis CHCV-genotype 1 infection.•We detected RAVs in 2 patients before any exposure to protease inhibitors.•At the time of virologic failure, RAVs were detectable in all patients tested.•Double/triple RAVs were selected in patients remaining viremic on therapy.

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关键词

DAA,HCV,IC50,IU/mL,LLD,LLQ,P/R,SVR

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