Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance.

Chara A Pitta,Panagiotis Papageorgis,Christiana Charalambous,Andreas I Constantinou

Cancer Letters（2013）

引用 13|浏览6

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摘要

•ER-β is silenced in MCF-7 cells with acquired tamoxifen resistance.•Treatment with the 5-AZA/TSA re-sensitizes cells to the inhibitory effects of 4-OHT.•Transfection with an ER-β expression vector sensitized resistant cells to 4-OHT.•ER-β re-expression alone is sufficient to restore sensitivity to tamoxifen.

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关键词

5-AZA,DNMT,E2,ER-α,ER-β,HDAC,4-OHT,MTT,SERMs,TSA

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