CA-074Me, a cathepsin B inhibitor, decreases APP accumulation and protects primary rat cortical neurons treated with okadaic acid.

Kwangmin Cho,Seung Yong Yoon,Jung Eun Choi,Hoe Jin Kang,He Yoon Jang,Dong-Hou Kim

Neuroscience Letters（2013）

引用 24|浏览3

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摘要

•Lysosomal activity is increased in OA-treated cortical neuron.•CA-074Me has a protective effect on OA-treated cortical neuron.•CA-074Me reduces APP accumulation in OA-treated cortical neuron.

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关键词

Alzheimer's disease,Lysosome,Okadaic acid,CA074-Me

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