CYP2C9 genotype and association with bone mineral density: a pilot study.

Sophie Brunner-Ziegler,Georgiana-Aura Giurgea,Raute Sunder-Plassmann,Alexandra Hammer,Christian Margeta,Martin Brunner,Renate Koppensteiner,Christine Mannhalter

Gene（2013）

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摘要

•CYP2C9*2 and CYP2C9*3 influence the response to oral anticoagulant drugs.•Oral anticoagulant drugs are positively associated with the risk for osteoporosis.•CYP2C9 mutations are significantly associated with reduced BMD.•CYP2C9 polymorphisms–linked bone loss may be mediated via glucocorticoid synthesis.

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关键词

BMD,SNP,CYP2C9,DEXA,BMI

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