Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1.

Stefanie C Huelsenbeck,Dennis Roggenkamp,Martin May,Johannes Huelsenbeck,Cord Brakebusch,Klemens Rottner,Markus Ladwein,Ingo Just,Gerhard Fritz,Gudula Schmidt,Harald Genth

The International Journal of Biochemistry & Cell Biology（2013）

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摘要

•E. coli cytotoxic necrotizing factor 1 induces expression of the cell death-regulating GTPase RhoB.•RhoB expression is based on transcriptional activation and involves Rac1-c-Myc signaling.•RhoB suppresses cell cycle progression and cell death in CNF1-treated cells.

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关键词

CNF1,CNF1,TcdA,TcdB,TcsL

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