DNA synthesis inhibition in response to benzo[a]pyrene dihydrodiol epoxide is associated with attenuation of p(34)cdc2: Role of p53.

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2013）

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摘要

•BPDE inhibits cell growth and DNA synthesis in different cell lines.•BPDE attenuates p34cdc2 expression level and induce p53 and p21 accumulation.•p34cdc2 attenuation not p53 accumulation corresponds to cell growth inhibition.•Interestingly p34cdc2 attenuation by BPDE is p53 dependent.•Role of p53 activation not p53 accumulation is implicated in cdc2 attenuation.

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关键词

(±)-Anti-benzo[a]pyrene-7,8-diol-9,10-epoxide,p34cdc2,p53,DNA synthesis,p21,Cell growth inhibition

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