A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

Joanna Kaplon,Liang Zheng,Katrin Meissl,Barbara Chaneton,Vitaly A. Selivanov,Gillian Mackay,Sjoerd H. van der Burg,Elizabeth M. E. Verdegaal,Marta Cascante,Tomer Shlomi,Eyal Gottlieb,Daniel S. Peeper

NATURE（2013）

引用 617|浏览15

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摘要

Pyruvate dehydrogenase (PDH) is identified as a crucial mediator of BRAF V600E -induced cellular senescence: PDH is activated by BRAF-mediated suppression of PDK1, enhancing oxidative glucose metabolism, and PDK1 depletion eradicates mutant BRAF melanomas, indicating that this relationship between cell senescence and metabolism might be exploited therapeutically.

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关键词

senescence,cancer

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