Ectopic hair cell-like cell induction by Math1 mainly involves direct transdifferentiation in neonatal mammalian cochlea.

Juanmei Yang,Ning Cong,Zhao Han,Yibo Huang,Fanglu Chi

Neuroscience Letters（2013）

引用 34|浏览2

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摘要

•LER cells possessed high ability to proliferate post-explanted.•LER cells cannot differentiate into hair cells without Math1 expression.•LER cells induced to hair cell-like cells by Math1 mainly via direct transdifferentiation.•Newly formed hair cells cannot divide.

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关键词

Math1/Atoh1,Lateral epithelial ridge (LER),Direct transdifferentiation,BrdU incorporation test

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