Natural and inducible T H 17 cells are regulated differently by Akt and mTOR pathways

Jiyeon S Kim,Tammarah Sklarz,Lauren B Banks,Mercy Gohil,Adam T Waickman,Nicolas Skuli,Bryan L Krock,Chong T Luo,Weihong Hu,Kristin N Pollizzi,Ming O Li,Jeffrey C Rathmell,Morris J Birnbaum,Jonathan D Powell,Martha S Jordan,Gary A Koretzky

NATURE IMMUNOLOGY（2013）

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摘要

The Akt-mTOR axis influences cell activation, differentiation and metabolism. Jordan and colleagues show that thymic and inducible T H 17 cells exhibit different requirements for mTORC1 and mTORC2 as well as Akt isoforms.

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nature immunology, science

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