Complement C3f serum levels may predict breast cancer risk in women with gross cystic disease of the breast.
Journal of Proteomics(2013)
摘要
Gross cystic disease (GCDB) is a breast benign condition predisposing to breast cancer. Cryopreserved sera from GCDB patients, some of whom later developed a cancer (cases), were studied to identify potential risk markers. A MALDI-TOF mass spectrometry analysis found several complement C3f fragments having a significant increased abundance in cases compared to controls. After multivariate analysis, the full-length form of C3f maintained a predictive value of breast cancer risk. Higher levels of C3f in the serum of women affected by a benign condition like GCDB thus appears to be correlated to the development of breast cancer even 20years later.
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关键词
Complement C3f,Serum,Peptidome profile,MALDI-TOF,Breast cancer risk
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