PF-04691502 triggers cell cycle arrest, apoptosis and inhibits the angiogenesis in hepatocellular carcinoma cells.

Feng-Ze Wang,Peng-Jiao,Na-Na Yang, Chuang-Yuan,Ya-Li Zhao,Qiang-Qiang Liu,Hong-Rong Fei,Ji-Guo Zhang

Toxicology Letters（2013）

引用 18|浏览5

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摘要

•PF-04691502 induces cell cycle arrest through regulating cyclinD1 and p27.•PF-04691502 triggers apoptosis via a mitochondrial pathway.•Growth factors-induced tube formation and migration of HUVECs are inhibited by PF-04691502 treatment.•PF-04691502 inhibits the expression of VEGF and HIF-1α.

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关键词

PF-04691502,PI3K/Akt,Cell cycle,Apoptosis,Angiogenesis

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