Histidine-Rich Protein 2 Plasma Levels Predict Progression To Cerebral Malaria In Malawian Children With Plasmodium Falciparum Infection
JOURNAL OF INFECTIOUS DISEASES(2013)
摘要
Some children with uncomplicated malaria progress to cerebral malaria despite appropriate treatment; identifying them in advance might improve their care. The objective of this study was to determine if plasma concentrations of a malaria protein, HRP2 (histidine-rich protein 2) would serve this purpose. Cases and controls were children presenting with uncomplicated malaria; the cases (n = 25) developed cerebral malaria, and the controls (n = 125) did not. Mean plasma HRP2 concentrations were significantly higher in the cases, and an HRP2 cutoff was identified that could predict disease progression (sensitivity and specificity, 88% for each). Quantitative measurements of HRP2 may be a useful screening tool.
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关键词
cerebral malaria, HRP2, malaria diagnostics
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