Quantitative Structure Activity Relationship between Diazabicyclo[4.2.0]octanes Derivatives and Nicotinic Acetylcholine Receptor Agonists.

Three dimensional quantitative structure activity relationship between diazabicyclo[4.2.0]octanes and nicotinic acetylcholine receptor (h alpha 4 beta 2 and h alpha 3 beta 4) agonists was studied using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA). From 11 CoMFA and CoMSIA models, CoMSIA with steric and electrostatic fields gave the best predictive models (q(2) = 0.926 and 0.945, r(ncv)(2) = 0.983 and 0.988). This study can be used to develop potent h alpha 4 beta 2 receptor agonists with low activity on h alpha 3 beta 4 subtype.