The use of sialidase therapy for respiratory viral infections.

•DAS181 is a novel inhaled therapy for the treatment of influenza.•Treatment targets sialic acid on the cell surface.•The sialidase removes both α2-3 and α2-6 linked sialic acids.•The use of an amphiregulin tag to the sialidase anchors it to the cell surface.•Treatment for 3days appears effective in treating influenza and parainfluenza.