Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
Marcel den Hoed,Mark Eijgelsheim,Tõnu Esko,Bianca J J M Brundel,David S Peal,David M Evans,Ilja M Nolte,Ayellet V Segrè,Hilma Holm,Robert E Handsaker,Harm-Jan Westra,Toby Johnson,Aaron Isaacs,Jian Yang,Alicia Lundby,Jing Hua Zhao,Young Jin Kim,Min Jin Go,Peter Almgren,Murielle Bochud,Gabrielle Boucher,Marilyn C Cornelis,Daniel Gudbjartsson,David Hadley,Pim van der Harst,Caroline Hayward,Martin den Heijer,Wilmar Igl,Anne U Jackson,Zoltán Kutalik,Jian'an Luan,John P Kemp,Kati Kristiansson,Claes Ladenvall,Mattias Lorentzon,May E Montasser,Omer T Njajou,Paul F O'Reilly,Sandosh Padmanabhan,Beate St. Pourcain,Tuomo Rankinen,Perttu Salo,Toshiko Tanaka,Nicholas J Timpson,Veronique Vitart,Lindsay Waite,William Wheeler,Weihua Zhang,Harmen H M Draisma,Mary F Feitosa,Kathleen F Kerr,Penelope A Lind,Evelin Mihailov,N Charlotte Onland-Moret,Ci Song,Michael N Weedon,Weijia Xie,Loic Yengo,Devin Absher,Christine M Albert,Alvaro Alonso,Dan E Arking,Paul I W de Bakker,Beverley Balkau,Cristina Barlassina,Paola Benaglio,Joshua C Bis,Nabila Bouatia-Naji,Søren Brage,Stephen J Chanock,Peter S Chines,Mina Chung,Dawood Darbar,Christian Dina,Marcus Dörr,Paul Elliott,Stephan B Felix,Krista Fischer,Christian Fuchsberger,Eco J C de Geus,Philippe Goyette,Vilmundur Gudnason,Tamara B Harris,Anna-Liisa Hartikainen,Aki S Havulinna,Susan R Heckbert,Andrew A Hicks,Albert Hofman,Suzanne Holewijn,Femke Hoogstra-Berends,Jouke-Jan Hottenga,Majken K Jensen,Åsa Johansson,Juhani Junttila,Stefan Kääb,Bart Kanon,Shamika Ketkar,Kay-Tee Khaw,Joshua W Knowles, Angrad S Kooner,Jan A Kors,Meena Kumari,Lili Milani, Päivi Laiho,Edward G Lakatta,Claudia Langenberg,Maarten Leusink,Yongmei Liu,Robert N Luben,Kathryn L Lunetta,Stacey N Lynch,Marcello R P Markus,Pedro Marques-Vidal,Irene Mateo Leach,Wendy L McArdle,Steven A McCarroll,Sarah E Medland, Kathryn A Miller,Grant W Montgomery,Alanna C Morrison,Martina Müller-Nurasyid,Pau Navarro,Mari Nelis,Jeffrey R O'Connell,Christopher J O'Donnell,Ken K Ong,Anne B Newman,Annette Peters,Ozren Polasek,Anneli Pouta,Peter P Pramstaller,Bruce M Psaty,Dabeeru C Rao,Susan M Ring,Elizabeth J Rossin,Diana Rudan,Serena Sanna,Robert A Scott,Jaban S Sehmi,Stephen Sharp,Jordan T Shin,Andrew B Singleton,Albert V Smith,Nicole Soranzo,Tim D Spector,Chip Stewart,Heather M Stringham,Kirill V Tarasov,André G Uitterlinden,Liesbeth Vandenput,Shih-Jen Hwang,John B Whitfield,Cisca Wijmenga,Sarah H Wild,Gonneke Willemsen, James F Wilson,Jacqueline C M Witteman,Andrew Wong,Quenna Wong,Yalda Jamshidi,Paavo Zitting,Jolanda M A Boer,Dorret I Boomsma,Ingrid B Borecki,Cornelia M van Duijn,Ulf Ekelund,Nita G Forouhi,Philippe Froguel,Aroon Hingorani,Erik Ingelsson,Mika Kivimaki,Richard A Kronmal,Diana Kuh,Lars Lind,Nicholas G Martin,Ben A Oostra,Nancy L Pedersen,Thomas Quertermous,Jerome I Rotter,Yvonne T van der Schouw,W M Monique Verschuren,Mark Walker,Demetrius Albanes,David O Arnar,Themistocles L Assimes,Stefania Bandinelli,Michael Boehnke,Rudolf A de Boer,Claude Bouchard,W L Mark Caulfield,John C Chambers,Gary Curhan,Daniele Cusi,Johan Eriksson,Luigi Ferrucci,Wiek H van Gilst,Nicola Glorioso,Jacqueline de Graaf,Leif Groop,Ulf Gyllensten,Wen-Chi Hsueh,Frank B Hu,Heikki V Huikuri,David J Hunter,Carlos Iribarren,Bo Isomaa,Marjo-Riitta Jarvelin,Antti Jula,Mika Kähönen,Lambertus A Kiemeney,Melanie M van der Klauw,Jaspal S Kooner,Peter Kraft,Licia Iacoviello,Terho Lehtimäki,Marja-Liisa L Lokki,Braxton D Mitchell,Gerjan Navis,Markku S Nieminen,Claes Ohlsson,Neil R Poulter,Lu Qi,Olli T Raitakari,Eric B Rimm,John D Rioux,Federica Rizzi,Igor Rudan,Veikko Salomaa,Peter S Sever,Denis C Shields,Alan R Shuldiner,Juha Sinisalo,Alice V Stanton,Ronald P Stolk,David P Strachan,Jean-Claude Tardif,Unnur Thorsteinsdottir,Jaako Tuomilehto,Dirk J van Veldhuisen,Jarmo Virtamo,Jorma Viikari,Peter Vollenweider,Gérard Waeber,Elisabeth Widen,Yoon Shin Cho,Jesper V Olsen,Peter M Visscher,Cristen Willer,Lude Franke,Jeanette Erdmann,John R Thompson,Arne Pfeufer,Nona Sotoodehnia,Christopher Newton-Cheh,Patrick T Ellinor,Bruno H Ch Stricker,Andres Metspalu,Markus Perola,Jacques S Beckmann,George Davey Smith,Kari Stefansson,Nicholas J Wareham,Patricia B Munroe,Ody C M Sibon,David J Milan,Harold Snieder,Nilesh J Samani,Ruth J F Loos
NATURE GENETICS（2013）
引用 270|浏览158
摘要
Ruth Loos and colleagues report a meta-analysis of genome-wide association studies in 181,171 individuals identifying 14 new loci associated with heart rate and test these for association with cardiac conduction, rhythm disorders and cardiovascular disease. Their experimental studies in Drosophila melanogaster and zebrafish models provide support for a role for 20 candidate genes at 11 of these loci in regulation of heart rate.
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关键词
heart rate–associated,cardiac conduction,loci,rhythm
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