First experience using peptide receptor radionuclide therapy in a patient with urothelial carcinoma.

A 78-year-old man with urothelial carcinoma metastasis after surgical resection of the right kidney, part of the ureter, and urinary bladder in May 2003 and 3 cycles of chemotherapy with cisplatin-gemcitabine was referred for peptide receptor radionuclide therapy (PRRT). Somatostatin-receptor profile was assessed by Ga-68-labeled lanreotide PET, and PRRT was performed using 3738 MBq (101 mCi) of Y-90-DOTA-lanreotide. Because of adequate PRRT response confirmed with MRI and F-18-FDG PET, surgical resection of the solitary cervical metastasis was feasible. Treatment was well tolerated, and the patient remains in complete remission from his urothelial carcinoma.