Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment

Britta Will,Thomas O Vogler,Boris Bartholdy,Francine Garrett-Bakelman,Jillian Mayer,Laura Barreyro,Ashley Pandolfi,Tihomira I Todorova,Ujunwa C Okoye-Okafor,Robert F Stanley,Tushar D Bhagat,Amit Verma,Maria E Figueroa,Ari Melnick,Michael Roth,Ulrich Steidl

NATURE IMMUNOLOGY（2013）

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摘要

How hematopoietic stem cells coordinate self-renewal and differentiation remains unclear. Steidl and colleagues show that the transcription factor and chromatin remodeler Satb1 is required for their self-renewal.

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nature immunology, science

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