Asymmetric methallylation of ketones catalyzed by a highly active organocatalyst 3,3'-F2-BINOL.

Yongda Zhang,Ning Li,Bo Qu,Shengli Ma,Heewon Lee,Nina C Gonnella,Joe Gao, Wenjie Li,Zhulin Tan,Jonathan T Reeves,Jun Wang,Jon C Lorenz,Guisheng Li,Diana C Reeves,Ajith Premasiri,Nelu Grinberg,Nizar Haddad,Bruce Z Lu,Jinhua J Song,Chris H Senanayake

ORGANIC LETTERS（2013）

引用 49|浏览14

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摘要

(S)-3,3'-F-2-BINOL has been synthesized for the first time and demonstrated as a highly active organocatalyst for asymmetric methallylation of ketones. Up to 98:2 enantioselectivity and 99% yield were obtained with 5 mol % catalyst loading. The catalyst (S)-3,3'-F-2-BINOL could be easily recovered and reused.

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