A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly

Daniele Canzio,Maofu Liao,Nariman Naber,Edward Pate,Adam Larson,Shenping Wu,Diana B. Marina,Jennifer F. Garcia,Hiten D. Madhani,Roger Cooke,Peter Schuck,Yifan Cheng,Geeta J. Narlikar

NATURE（2013）

引用 180|浏览2

暂无评分

摘要

The Schizosaccharomyces pombe HP1 protein, Swi6, is shown to exist in an auto-inhibited state when unbound to chromatin, switching to a spreading-competent state upon binding to the HK9 methyl mark; disrupting this switch affects heterochromatin assembly and gene silencing.

查看译文

关键词

DNA, Chromatin

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要