N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections.

Yanming Du,Hong Ye,Tina Gill,Lijuan Wang,Fang Guo,Andrea Cuconati,Ju-Tao Guo,Timothy M Block,Jinhong Chang,Xiaodong Xu

Bioorganic & Medicinal Chemistry Letters（2013）

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摘要

Novel N-alkyldeoxynojirimycins (NADNJs) with two hydrophobic groups attached to a nitrogen linker on the alkyl chain were designed. A novel NADNJ 24 containing a terminal tertiary amide was discovered that was a potent inhibitor against BVDV, Dengue, and Tacaribe.

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关键词

N-Alkyldeoxynojirimycin,Tertiary amide,Hydrophobic interaction,Antiviral,Dengue,Tacaribe

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