EGFL7 ligates αvβ3 integrin to enhance vessel formation

Blood, Volume 121, Issue 15, 2013, Pages 3041-3050.

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摘要

Angiogenesis, defined as blood vessel formation from a preexisting vasculature, is governed by multiple signal cascades including integrin receptors, in particular integrin αVβ3. Here we identify the endothelial cell (EC)-secreted factor epidermal growth factor-like protein 7 (EGFL7) as a novel specific ligand of integrin αVβ3, thus provi...更多

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