Inhaled pan-selectin antagonist Bimosiamose attenuates airway inflammation in COPD.

Henrik Watz,Daniel Bock,Michael Meyer,Katrin Schierhorn,Karin Vollhardt,Christiane Woischwill,Frauke Pedersen,Anne Kirsten,Kai-Michael Beeh,Wolfgang Meyer-Sabellek,Helgo Magnussen,Jutta Beier

Pulmonary Pharmacology & Therapeutics（2013）

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摘要

Selectins, a family of cell adhesion molecules, are involved in leukocyte extravasation to sites of inflammation. We investigated the safety and efficacy of the inhaled pan-selectin antagonist Bimosiamose in patients with chronic obstructive pulmonary disease (COPD).

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关键词

COPD,Airway inflammation,Pan-selectin antagonism

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