Hmw-Adiponectin Associates With Triglyceride Concentrations In Type 1 Diabetic Patients

Aim: The objective of this study was to investigate the relation between serum high molecular weight (HNM-adiponectin concentration and fasting and postprandial blood glycemic and lipid parameters in type 1 diabetic patients. Methods: Type 1 diabetic patients treated with short-acting insulin analogs and healthy volunteers were recruited. The subjects were divided into two groups based on the mean HNM-adiponectin value of 12.2 mg/L: low HMW-adiponectin (men/women = 7/2) and high HMW-adiponectin (men/women=3/8). Blood samples were collected after art overnight fast, and 30-180 min after consuming white bread (B) or white bread with butter (BB). Results: Type 1 diabetic patients with high HNM-adiponectin had lower triglyceride and remnant like particle (RLP)-triglyceride concentrations than those with low HMW-adiponectin (p<0.01), and had a higher lipoprotein lipase mass (p < 0.01) than healthy subjects (men/women = 8/6). After B and BB meals, type I diabetic patients with high HMW-adiponectin consistently had lower triglyceride and RLP-triglyceride concentrations for up to 180 min than those with low HMW-adiponectin (p<0.01); however, apoB48 did not differ between these two groups. Fasting and postprandial plasma glucose were higher in both diabetic groups than in healthy subjects (p < 0.001), with no significant difference between patient groups. Conclusion: HMW-adiponectin is more strongly associated with very low density lipoprotein remnant metabolism than glucose utilization in type I diabetic patients receiving short-acting insulin analogs.