Effect of oral antigen and antibody exposure at birth on subsequent immune status. A study in neonatal pigs.
International archives of allergy and immunology(2009)
摘要
Overall, our data support the hypothesis that contrary to previous work in rodents, very early exposure of neonatal pigs to a single small dose of antigen can reduce subsequent immune responses. This may have implications for human health. However, although these data point to a reducing/regulatory effect of low doses of antigen in very young animals, they cannot be extrapolated directly to allergy.
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