Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme.

Mariangela Biava,Claudio Battilocchio,Giovanna Poce,Salvatore Alfonso,Sara Consalvi,Giulio Cesare Porretta,Silvia Schenone,Vincenzo Calderone,Alma Martelli,Lara Testai,Carla Ghelardini,Lorenzo Di Cesare Mannelli,Lidia Sautebin,Antonietta Rossi,Antonio Giordani,Paola Patrignani,Maurizio Anzini

European Journal of Medicinal Chemistry（2012）

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摘要

The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds.

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关键词

Cyclooxygenases,CINODS,Coxibs,1,5-Diarylpyrroles,Glycine derivatives,Nitric oxide

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