Farnesyl protein transferase inhibitory components of Polygonum multiflorum
Archives of pharmacal research(2009)
摘要
The methanolic extract of the roots of Polygonum multiflorum (Polygonaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two anthraquinone glycosides, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner.
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关键词
Polygonum multiflorum
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