Process Research And Development For A Tetrazole-Based Growth Hormone Secretagogue (Ghs) Pharmaceutical Development Candidate
JOURNAL OF ORGANIC CHEMISTRY(2009)
摘要
BMS-317180 (1) is a potent, orally active agonist of the human growth hormone secretagogue (GHS) receptor. This manuscript details the process research and development efforts that enabled the synthesis of the phosphate salt of 1 on a multi-kilogram scale. Key considerations in the development of this process focused on safe execution and the requirement for telescoped synthetic transformations (i.e., without isolation of intermediate products) to contend with a lack of suitably crystalline products.
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关键词
growth hormone secretagogue,tetrazole-based
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