The CD46-Jagged1 interaction is critical for human T H 1 immunity

Gaëlle Le Friec,Devon Sheppard,Pat Whiteman,Christian M Karsten, Salley Al-Tilib Shamoun,Adam Laing,Laurence Bugeon,Margaret J Dallman,Teresa Melchionna, Chandramouli Chillakuri,Richard A Smith,Christian Drouet,Lionel Couzi,Veronique Fremeaux-Bacchi,Jörg Köhl,Simon N Waddington,James M McDonnell,Alastair Baker,Penny A Handford,Susan M Lea,Claudia Kemper

NATURE IMMUNOLOGY（2012）

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摘要

The complement receptor CD46 and the Notch-Jagged system are important for the differentiation of helper T cells. Kemper and colleagues demonstrate that Jagged1 is a physiological ligand for CD46 and is critical for the generation of T helper type 1 cells in humans.

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关键词

calcium binding proteins,antigens,cultured,rna interference,interleukin 10,cd46,rna,membrane proteins,transgenic

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