ImmunoPET imaging of phosphatidylserine in pro-apoptotic therapy treated tumor models.
Nuclear Medicine and Biology(2013)
摘要
An immunoPET imaging probe for the detection of phosphatidylserine was developed and tested in animal models of human cancer treated with pro-apoptotic therapy. We hypothesized that the relatively long plasma half-life of a probe based on a full-length antibody coupled with a residualizing radionuclide would be able to catch the wave of drug-induced apoptosis and lead to a specific accumulation in apoptotic tumor tissue.
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关键词
PET,Apoptosis,Cancer therapy,89Zr,Monoclonal antibodies
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