Global identification of peptidase specificity by multiplex substrate profiling

Anthony J O'Donoghue, A Alegra Eroy-Reveles,Giselle M Knudsen, Jessica Ingram,Min Zhou,Jacob B Statnekov,Alexander L Greninger,Daniel R Hostetter,Gang Qu,David A Maltby,Marc O Anderson,Joseph L DeRisi,James H McKerrow,Alma L Burlingame,Charles S Craik

Nature methods（2012）

引用 126|浏览19

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摘要

synthetic peptide library in conjunction with liquid chromatography–tandem mass spectrometry identifies the specificities of endo- and exopeptidases without requiring enrichment of substrates or products.

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关键词

Biochemistry, Bioinformatics, Mass Spectrometry, Chemical Biology

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