Ago-allosteric modulators of human glucagon-like peptide 2 receptor.

Kazuto Yamazaki,Hiroki Terauchi,Daisuke Iida,Hironori Fukumoto,Shuichi Suzuki,Takaki Kagaya,Mika Aoki,Koichiro Koyama,Takashi Seiki,Kazuma Takase,Misako Watanabe,Tohru Arai,Kappei Tsukahara,Junichi Nagakawa

Bioorganic & Medicinal Chemistry Letters（2012）

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摘要

Methyl 2-{[(2Z)-2-(2,5-dichlorothiophen-3-yl)-2-(hydroxyimino)ethyl]sulfanyl}benzoate (compound 1) and its derivatives were discovered as compounds having properties of both agonists and allosteric positive modulators of human glucagon-like peptide 2 receptor, a class-B G protein-coupled receptor.

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关键词

Glucagon-like peptide 2,Agonist,Positive allosteric modulator

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