Novel monobactams utilizing a siderophore uptake mechanism for the treatment of Gram-negative infections (vol 22, pg 5989, 2012)
Mark J. Mitton-Fry,Joel T. Arcari,Matthew F. Brown,Jeffrey M. Casavant,Steven M. Finegan,Mark E. Flanagan,Hongying Gao,David M. George,Brian S. Gerstenberger,Seungil Han,Joel R. Hardink,Thomas M. Harris,Thuy Hoang,Michael D. Huband,Rebecca Irvine,Manjinder S. Lall,M. Megan Lemmon,Chao Li,Jian Lin,Sandra P. McCurdy,John P. Mueller,Lisa Mullins,Mark Niosi,Mark C. Noe,David Pattavina,Joseph Penzien,Mark S. Plummer, Hud Risley,Brandon P. Schuff,Veerabahu Shanmugasundaram,Jeremy T. Starr,Jianmin Sun, Jennifer Winton,Jennifer A. Young Bioorganic & Medicinal Chemistry Letters（2015）
摘要
Novel siderophore-linked monobactams with in vitro and in vivo anti-microbial activity against MDR Gram-negative pathogens are described.
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关键词
Monobactam,Gram-negative,Pseudomonas aeruginosa,Klebsiella pneumoniae,Escherichia coli,Siderophore,MC-1
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