First Experience With Direct Factor Xa Inhibition In Patients With Stable Coronary Disease - A Pharmacokinetic And Pharmacodynamic Evaluation

Background-Thrombin generation is critical to the formation of an arterial thrombus after rupture of an atherosclerotic plaque. In patient,, with stable coronary disease receiving Standard medical therapy. we evaluated the pharmacokinetics. pharmacodynamics, and safety profile of DX-9065a. a novel small-molecule anticoagulant that directly, selectively. and reversibly inhihits factor Xa.Methods and Results-In a double-blind trial, 73 patients (median age, 63 hearse 29% women) were randomly, assigned to receive a fixed-dose intravenous bolus, Followed by a 72-hour infusion of placebo or 1 of 4 weight-adjusted regimens of DX-9005a, Plasma samples were collected during infusion and a 24-hour elimination period. Only minor bleeding occured predominantly ecchymoses at infusion sites. and its incidence did not differ significantly among the groups, including placebo. Median hemoglobin, platelet count, serum creatinine level, and liver function tests did not chan-e significantly from baseline during infusion or elimination. Significant predictors of pharmacokinetic response included infusion dose and weight. At 60 hours into the DX-9065a infusion, plasma drug levels correlated strongly with anti-factor Xa activity (r=0.97). prothrombin time (r=0.77), and international normalized ratio (r=0.72) but less so with activated partial thromboplastin time (r=0.56 all P<0.001).Conclusions-This is the first study of a selective, reversible, and direct small-molecule factor Xa inhibitor in patients with stable coronary disease. These data lay the foundation for further investigation of factor Xa inhibitors in the treatment of patients with coronary atherothrombosis.