Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases.

Michael L Curtin,H Robin Heyman,Robin R Frey,Patrick A Marcotte,Keith B Glaser,James R Jankowski,Terrance J Magoc,Daniel H Albert,Amanda M Olson,David R Reuter,Jennifer J Bouska,Debra A Montgomery,Joann P Palma,Cherrie K Donawho,Kent D Stewart,Chris Tse,Michael R Michaelides

Bioorganic & Medicinal Chemistry Letters（2012）

引用 16|浏览19

暂无评分

摘要

A series of pyrazole diaminopyrimidines with dual KDR/Aurora B kinase inhibitory activity has been identified. The SAR, physiochemical properties and antitumor activity of this series (e.g., (+)-38) are discussed.

查看译文

关键词

Aurora B kinase inhibitors,KDR kinase inhibitors,Diaminopyrimidines,Aminopyrazoles,Antitumor activity

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要