Assessment of gene-by-sex interaction effect on bone mineral density.

Ching-Ti Liu,Karol Estrada,Laura M Yerges-Armstrong,Najaf Amin,Evangelos Evangelou,Guo Li,Ryan L Minster,Melanie A Carless,Candace M Kammerer,Ling Oei,Yanhua Zhou,Nerea Alonso,Zoe Dailiana,Joel Eriksson,Natalia García-Giralt,Sylvie Giroux,Lise Bjerre Husted,Rita I Khusainova,Theodora Koromila,Annie Waichee Kung,Joshua R Lewis,Laura Masi,Simona Mencej-Bedrac,Xavier Nogues,Millan S Patel,Janez Prezelj,J Brent Richards,Pak Chung Sham,Timothy Spector,Liesbeth Vandenput,Su-Mei Xiao,Hou-Feng Zheng,Kun Zhu,Susana Balcells,Maria Luisa Brandi,Morten Frost,David Goltzman,Jesús González-Macías,Magnus Karlsson,Elza K Khusnutdinova,Panagoula Kollia,Bente Lomholt Langdahl,Osten Ljunggren,Mattias Lorentzon,Janja Marc,Dan Mellström,Claes Ohlsson,José M Olmos,Stuart H Ralston,José A Riancho,François Rousseau,Roser Urreizti,Wim Van Hul,María T Zarrabeitia,Martha Castano-Betancourt,Serkalem Demissie,Elin Grundberg,Lizbeth Herrera,Tony Kwan,Carolina Medina-Gómez,Tomi Pastinen,Gunnar Sigurdsson,Gudmar Thorleifsson, Joyce Bj Vanmeurs,John Blangero,Albert Hofman,Yongmei Liu,Braxton D Mitchell,Jeffrey R O'Connell,Ben A Oostra,Jerome I Rotter,Kari Stefansson,Elizabeth A Streeten,Unnur Styrkarsdottir,Unnur Thorsteinsdottir,Frances A Tylavsky,Andre Uitterlinden,Jane A Cauley,Tamara B Harris,John Pa Ioannidis,Bruce M Psaty,John A Robbins,M Carola Zillikens, Cornelia M Vanduijn,Richard L Prince,David Karasik,Fernando Rivadeneira,Douglas P Kiel,L Adrienne Cupples,Yi-Hsiang Hsu

JOURNAL OF BONE AND MINERAL RESEARCH（2012）

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摘要

Sexual dimorphism in various bone phenotypes, including bone mineral density (BMD), is widely observed; however, the extent to which genes explain these sex differences is unclear. To identify variants with different effects by sex, we examined gene-by-sex autosomal interactions genome-wide, and performed expression quantitative trait loci (eQTL) analysis and bioinformatics network analysis. We conducted an autosomal genome-wide meta-analysis of gene-by-sex interaction on lumbar spine (LS) and femoral neck (FN) BMD in 25,353 individuals from 8 cohorts. In a second stage, we followed up the 12 top single-nucleotide polymorphisms (SNPs; p?更多

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关键词

GENE-BY-SEX INTERACTION,BMD,ASSOCIATION,AGING

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