Severity of meningococcal disease in children and the angiotensin-converting enzyme insertion/deletion polymorphism

American journal of respiratory and critical care medicine, Volume 165, Issue 8, 2002, Pages 1103-1106.

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Abstract:

Critical illness outcome may be causally related to inflammatory response severity. Given that tissue angiotensin-converting-enzyme (ACE) regulates such responses and that the deletion (D) [rather than insertion (I)] variant of the ACE gene is associated with higher tissue ACE levels, DD genotype might be associated with a poorer outcome ...More

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