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Finger Loop Inhibitors of the Hcv Ns5b Polymerase. Part Ii. Optimization of Tetracyclic Indole-Based Macrocycle Leading to the Discovery of Tmc647055

Sandrine Vendeville,Tse-I Lin,Lili Hu,Abdellah Tahri,David McGowan,Maxwell D. Cummings,Katie Amssoms,Maxime Canard,Stefaan Last,Iris Van den Steen,Benoit Devogelaere,Marie-Claude Rouan,Leen Vijgen,Jan Martin Berke,Pascale Dehertogh,Els Fransen,Erna Cleiren,Liesbet Van der Helm,Gregory Fanning,Kristof Van Emelen,Origene Nyanguile,Kenny Simmen,Pierre Raboisson

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2012）

Cited 40|Views21
Key words
Hepatitis C virus,NS5b polymerase,Allosteric inhibitor,Macrocycle
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