The discovery of equipotent PPARalpha/gamma dual activators.

Paul Martres,Nicolas Faucher,Alain Laroze,Olivier Pineau,Marie Helene Fouchet,Florent Potvain,Didier Grillot,Veronique Beneton

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2008）

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摘要

We report the design and synthesis of equipotent PPARalpha/gamma dual agonists starting from selective PPAR alpha agonist 1. In vivo data for 7 in the Zucker fa/fa rat are presented.

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关键词

PPAR alpha, PPAR gamma, Dual, Agonist

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