Linear Chromosome-generating System of Agrobacterium tumefaciens C58: PROTELOMERASE GENERATES AND PROTECTS HAIRPIN ENDS

Wai Mun Huang, Jeanne DaGloria, Heather Fox,Qiurong Ruan, John Tillou, Ke Shi,Hideki Aihara, John Aron,Sherwood Casjens

Journal of Biological Chemistry(2012)

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摘要
Background: Protelomerase is an enzyme that generates closed hairpin ends in bacterial linear chromosomes.Results: Atu2523 encodes the agrobacterial protelomerase that generates its telomeres.Conclusion: Agrobacterial protelomerase is the most compact enzyme of its kind that can uniquely both form and bind hairpin telomeres.Significance: The studies of the reaction mechanism is crucial in understanding why and how and the prevalence of the existence of linear chromosome in bacteria.
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关键词
DNA Enzymes,DNA Structure,DNA-Protein Interaction,Microbiology,Mutant,Cleavage-rejoining,Hairpins,Protelomerase,Structure,Telomeres
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