In-transit sentinel nodes must be found: implication from a 10-year follow-up study in melanoma.

The aim was to study the occurrence of in-transit nodes at a preoperative lymphoscintigraphy for patients with primary melanoma, and to reveal their potential role in prognosis. From 1984 to 1996, 911 patients, hospitalized for wide excision of a clinically localized primary cutaneous head-neck or truncal melanoma, had a static lymphoscintigraphy on the day before surgery as part of a prospective protocol. Lymph nodes were in no case removed at the time of scintigraphy. Recurrence and survival patterns were compared for patients with in-transit nodes with the remaining patients with only regional nodes. Follow-up time was a minimum of 10 years. In-transit nodes were visualized by lymphoscintigraphy in 6% of the patients, 18% of whom had a later recurrence in this region. The melanomas in the in-transit node group were slightly thicker, and ulceration was slightly more frequent (neither significant). The in-transit node group had significantly more lymph node basins visualized at scintigraphy compared with the remaining group of patients with only regional nodes. The risk of recurrence and/or death from melanoma was significantly worse (P<0.05) in the in-transit node group compared with the remaining patients. The clinical significance of the in-transit nodes, occasionally seen in melanoma patients (also in stage la), may suggest a slightly poorer prognosis and a substantial risk of a later recurrence in the in transit region. We therefore recommend that in-transit nodes must be found and examined exactly as is done with locoregional sentinel nodes. Melanoma Res 18:359-364 (C) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.