PARP1 parylation promotes silent locus transmission in the nucleolus: the suspicion confirmed.
Molecular Cell（2012）
摘要
Parylation modulates various processes, including transcription. In this issue of Molecular Cell, Guetg et al. (2012) show that, in the nucleolus, PARP1-mediated parylation of TIP5 promotes the silencing of rDNA chromatin during replication, uncovering the mechanism by which PARP1 ensures that silent rDNA regions are properly inherited.
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