Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology.

Martin J Weissenborn,Roberto Castangia,Johannes W Wehner,Robert Šardzík,Thisbe K Lindhorst,Sabine L Flitsch

CHEMICAL COMMUNICATIONS（2012）

引用 26|浏览8

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摘要

We report a highly efficient and selective method for the coupling of peptides and glycoconjugates bearing N-terminal cysteines to activated surfaces. This chemoselective method generates stable amide linkages without using any thiol additives.

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