Structure-based development of bacterial nitroreductase against nitrobenzodiazepine-induced hypnosis.
Biochemical Pharmacology（2012）
摘要
Rational design of E. coli nitroreductase NfsB for the in vivo disposition of nitrobenzodiazepine (NBDZ) and shortening the duration of hypnosis.
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关键词
Nitrobenzodiazepine,Escherichia coli type I nitroreductase NfsB,Flunitrazepam,Rational protein design,Antidote
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