Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm
Cell, Volume 148, Issue 5, 2012, Pages 873-885.
Tumor heterogeneity presents a challenge for inferring clonal evolution and driver gene identification. Here, we describe a method for analyzing the cancer genome at a single-cell nucleotide level. To perform our analyses, we first devised and validated a high-throughput whole-genome single-cell sequencing method using two lymphoblastoid ...More
Full Text (Upload PDF)
PPT (Upload PPT)