Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm

    Cell, Volume 148, Issue 5, 2012, Pages 873-885.

    Cited by: 418|Bibtex|Views7|Links
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    Abstract:

    Tumor heterogeneity presents a challenge for inferring clonal evolution and driver gene identification. Here, we describe a method for analyzing the cancer genome at a single-cell nucleotide level. To perform our analyses, we first devised and validated a high-throughput whole-genome single-cell sequencing method using two lymphoblastoid ...More

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