Discovery of GS-9451: an acid inhibitor of the hepatitis C virus NS3/4A protease.

X Christopher Sheng,Todd Appleby,Thomas Butler,Ruby Cai,Xiaowu Chen,Aesop Cho,Michael O Clarke,Jeromy Cottell,William E Delaney,Edward Doerffler,John Link,Mingzhe Ji,Rowchanak Pakdaman,Hyung-Jung Pyun,Qiaoyin Wu,Jie Xu,Choung U Kim

Bioorganic & Medicinal Chemistry Letters（2012）

引用 50|浏览9

暂无评分

摘要

The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV NS3 protease inhibitors with greatly improved pharmacokinetic properties in rats, dogs and monkeys.

查看译文

关键词

HCV,GS-9451,NS3 Protease,Solubilizing group

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要