Uroplakins Do Not Restrict CO2 Transport through Urothelium

Florian Zocher,Mark L Zeidel,Andreas Missner,Tung-Tien Sun,Ge Zhou,Yi Liao,Maximilian von Bodungen,Warren G Hill,Susan Meyers,Peter Pohl,John C Mathai

Journal of Biological Chemistry（2012）

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摘要

Background: The tightness of various membrane barriers to CO2 is of unknown molecular origin.Results: The bladder tissue lacks carbonic anhydrase. The resulting low intra-epithelial CO2 concentration gives rise to the apparent CO2 impermeability.Conclusion: Uroplakins do not act to decrease transepithelial CO2 flux.Significance: Enzymatic regulation of CO2 abundance rules out that aquaporins significantly contribute to the maintenance of acid base homeostasis.

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关键词

Aquaporin,Carbon Dioxide,Membrane Biophysics,Permeability,Physiology,Scanning Electrochemical Microscopy,Unstirred Layers

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